Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA4 | P22748 | 2/20 | 0.34 |
| ▸ | CA5A | P35218 | 2/20 | 0.34 |
| ▸ | CA7 | P43166 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9849192 | 0.83 | LTA4H (0.44) | LMNAMEN1KMT2ALTA4HEPHX2 | |
| SCHEMBL4411677 | 0.83 | NPSR1 (0.47) | MEN1KMT2ALTA4HEPHX2NPSR1 | |
| SCHEMBL12229723 | 0.80 | NPSR1 (0.45) | MEN1KMT2ALTA4HEPHX2NPSR1 | |
| SCHEMBL8116136 | 0.77 | LTA4H (0.42) | LMNAMEN1KMT2ALTA4HEPHX2 | |
| SCHEMBL14809781 | 0.77 | MEN1 (0.43) | LMNAMEN1KMT2ALTA4HEPHX2 | |
| SCHEMBL12229683 | 0.77 | POLB (0.53) | LMNAMEN1KMT2ALTA4HEPHX2 | |
| SCHEMBL9849259 | 0.76 | NPC1 (0.45) | MEN1KMT2ALTA4HEPHX2HDAC1 | |
| SCHEMBL14809313 | 0.76 | MEN1 (0.48) | MEN1KMT2ALTA4HEPHX2NPSR1 | |
| SCHEMBL7189809 | 0.75 | NPSR1 (0.41) | MEN1KMT2ALTA4HEPHX2NPSR1 | |
| SCHEMBL14432434 | 0.74 | TAAR1 (0.53) | LMNAPOLBRAB9ATDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421436-A2 | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |