Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9849190 | 0.83 | EPHX2 (0.49) | NPC1RAB9ALTA4HEPHX2MAPT | |
| SCHEMBL4411677 | 0.83 | NPSR1 (0.47) | LTA4HEPHX2MEN1KMT2ACA12 | |
| SCHEMBL12229723 | 0.80 | NPSR1 (0.45) | LTA4HEPHX2MEN1KMT2ACA12 | |
| SCHEMBL14809313 | 0.79 | MEN1 (0.48) | LTA4HEPHX2MEN1KMT2A | |
| SCHEMBL8116136 | 0.77 | LTA4H (0.42) | NPC1MTNR1AMTNR1BFDFT1LTA4H | |
| SCHEMBL14809781 | 0.77 | MEN1 (0.43) | NPC1RAB9ALTA4HEPHX2MAPT | |
| SCHEMBL12229683 | 0.77 | POLB (0.53) | LTA4HEPHX2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9849286 | 0.76 | LMNA (0.42) | NPC1RAB9AFDFT1LTA4HEPHX2 | |
| SCHEMBL7189809 | 0.75 | NPSR1 (0.41) | FDFT1LTA4HEPHX2MEN1KMT2A | |
| SCHEMBL12229697 | 0.74 | NPSR1 (0.45) | LTA4HEPHX2MEN1KMT2ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421436-A2 | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | claimed |
| EP-0421436-A2 | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |