Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28046811 | 0.83 | TP53 (0.54) | TNKSTNKS2PARP1KDM4ELMNA | |
| SCHEMBL18698086 | 0.83 | KDM4E (0.52) | TNKSTNKS2PARP1KDM4ELMNA | |
| SCHEMBL439446 | 0.83 | KDM4E (0.43) | KDM4ELMNAHPGDTSHRHSD17B10 | |
| SCHEMBL31046570 | 0.83 | KDM4E (0.43) | KDM4ELMNAHPGDTSHRHSD17B10 | |
| SCHEMBL28192790 | 0.81 | TNKS (0.47) | TNKSTNKS2PARP1KDM4ELMNA | |
| SCHEMBL10760673 | 0.81 | LMNA (0.56) | KDM4ELMNACRHR1PSMB5 | |
| SCHEMBL9849276 | 0.81 | TNKS (0.47) | TNKSTNKS2PARP1KDM4ELMNA | |
| SCHEMBL27736306 | 0.81 | ALDH1A1 (0.41) | KDM4ELMNAHPGDALDH1A1MEN1 | |
| SCHEMBL17973332 | 0.81 | LMNA (0.51) | KDM4ELMNAHPGDTSHRHSD17B10 | |
| SCHEMBL1577814 | 0.79 | LMNA (0.67) | TNKSTNKS2PARP1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0446604-A2 | Pyridine and related aza heterocycle derivatives as cardiovascular agents | AMERICAN CYANAMID COMPANY (US) | 1991-09-18 | — | — | EP | disclosed |