Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 8/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1918785 | 0.84 | MEN1 (0.55) | KDM4EALDH1A1HPGDMAPTCYP1A2 | |
| SCHEMBL1904903 | 0.84 | CYP1A2 (0.53) | KDM4EALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL1323377 | 0.81 | MEN1 (0.43) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL1919134 | 0.81 | MEN1 (0.59) | KDM4EALDH1A1HPGDMAPTCYP1A2 | |
| SCHEMBL19220972 | 0.81 | KDM4E (0.51) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL26199891 | 0.80 | KIF11 (0.46) | KDM4EALDH1A1HPGDMAPTCYP1A2 | |
| SCHEMBL20657870 | 0.80 | KDM4E (0.45) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL17498399 | 0.77 | ALDH1A1 (0.70) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL10854716 | 0.77 | KDM4E (0.44) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL10844529 | 0.74 | CASP1 (0.50) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0446604-A2 | Pyridine and related aza heterocycle derivatives as cardiovascular agents | AMERICAN CYANAMID COMPANY (US) | 1991-09-18 | — | — | EP | disclosed |