Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9849299 | 0.82 | ALDH1A1 (0.65) | KDM4EALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL9849642 | 0.81 | ALDH1A1 (0.61) | KDM4EALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL9849435 | 0.78 | KDM4E (0.49) | KDM4EALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL9314099 | 0.76 | KDM4E (0.66) | KDM4EALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL9849555 | 0.72 | ALDH1A1 (0.43) | ALDH1A1GSK3AGSK3BGAATSHR | |
| SCHEMBL10856600 | 0.69 | CYP26A1 (0.54) | SMN1; SMN2NPC1POLB | |
| SCHEMBL24249663 | 0.69 | KDM4E (0.71) | KDM4EALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL1187744 | 0.69 | KDM4E (0.80) | KDM4EALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL9849578 | 0.67 | ALDH1A1 (0.61) | KDM4EALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL9849889 | 0.67 | GSK3A (0.64) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0446604-A2 | Pyridine and related aza heterocycle derivatives as cardiovascular agents | AMERICAN CYANAMID COMPANY (US) | 1991-09-18 | — | — | EP | disclosed |