Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | CASP1 | P29466 | 3/20 | 0.61 |
| ▸ | CASP7 | P55210 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CLK1 | P49759 | 1/20 | 0.61 |
| ▸ | SOD1 | P00441 | 3/20 | 0.53 |
| ▸ | QPCT | Q16769 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9849334 | 0.87 | KDM4E (0.53) | ALDH1A1HSD17B10KDM4EHPGDCASP1 | |
| SCHEMBL9849299 | 0.85 | ALDH1A1 (0.65) | ALDH1A1HSD17B10KDM4EHPGDCASP1 | |
| SCHEMBL9849642 | 0.82 | ALDH1A1 (0.61) | ALDH1A1HSD17B10KDM4EHPGDCASP1 | |
| SCHEMBL9849550 | 0.77 | QPCT (0.60) | ALDH1A1KDM4ETSHRSOD1QPCT | |
| SCHEMBL15757112 | 0.75 | NUDT1 (0.54) | ALDH1A1HSD17B10KDM4EHPGDCASP1 | |
| SCHEMBL3625365 | 0.74 | ALDH1A1 (0.54) | ALDH1A1HSD17B10KDM4EHPGDCASP1 | |
| SCHEMBL9706477 | 0.74 | MEN1 (0.58) | ALDH1A1HSD17B10KDM4EHPGDCASP1 | |
| SCHEMBL9849889 | 0.73 | GSK3A (0.64) | ALDH1A1HSD17B10KDM4ELMNASOD1 | |
| SCHEMBL3632615 | 0.73 | GSK3A (0.61) | ALDH1A1HSD17B10KDM4EHPGDPOLB | |
| SCHEMBL3629417 | 0.73 | TP53 (0.60) | ALDH1A1HSD17B10KDM4EHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0446604-A2 | Pyridine and related aza heterocycle derivatives as cardiovascular agents | AMERICAN CYANAMID COMPANY (US) | 1991-09-18 | — | — | EP | disclosed |