Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLR1 | P15328 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 2/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9850018 | 0.99 | FOLR1 (0.43) | FOLR1CYP2D6ALDH1A1LMNAPRNP | |
| SCHEMBL9849753 | 0.97 | FOLR1 (0.47) | FOLR1CYP2D6ALDH1A1LMNAPRNP | |
| SCHEMBL9849782 | 0.92 | FOLR1 (0.41) | FOLR1CYP2D6ALDH1A1LMNAPRNP | |
| SCHEMBL9849931 | 0.88 | HPGD (0.43) | FOLR1CYP2D6ALDH1A1LMNAPRNP | |
| SCHEMBL9849766 | 0.87 | HPGD (0.44) | FOLR1CYP2D6ALDH1A1LMNAPRNP | |
| SCHEMBL9850002 | 0.85 | HPGD (0.40) | FOLR1ALDH1A1LMNAPRNPRECQL | |
| SCHEMBL9849692 | 0.80 | MRGPRX4 (0.38) | FOLR1CYP2D6ALDH1A1LMNAHPGD | |
| SCHEMBL9849793 | 0.79 | DAO (0.36) | FOLR1CYP2D6ALDH1A1POLBKDM4E | |
| SCHEMBL9849829 | 0.78 | CYP2D6 (0.37) | CYP2D6DHFR | |
| SCHEMBL9849722 | 0.76 | DAO (0.46) | FOLR1CYP2D6DAODHFRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415510-A2 | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-03-06 | — | — | EP | disclosed |
| US-4920125-A | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1990-04-24 | — | — | US | disclosed |