Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 5/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9850002 | 0.93 | HPGD (0.40) | MRGPRX4DHFRPARP1NPSR1LMNA | |
| SCHEMBL9849931 | 0.93 | HPGD (0.43) | MRGPRX4DHFRPARP1NPSR1LMNA | |
| SCHEMBL9849766 | 0.92 | HPGD (0.44) | MRGPRX4DHFRPARP1NPSR1LMNA | |
| SCHEMBL9849782 | 0.87 | FOLR1 (0.41) | MRGPRX4DHFRLMNAATMFOLR1 | |
| SCHEMBL9849753 | 0.80 | FOLR1 (0.47) | DHFRLMNAFOLR1ALDH1A1CYP2D6 | |
| SCHEMBL9849759 | 0.80 | FOLR1 (0.44) | DHFRLMNAHPGDATMFOLR1 | |
| SCHEMBL9850018 | 0.79 | FOLR1 (0.43) | DHFRLMNAHPGDFOLR1ALDH1A1 | |
| SCHEMBL9849706 | 0.79 | DHFR (0.34) | DHFRNPSR1LMNAPPARGNCOA2 | |
| SCHEMBL9849678 | 0.77 | DAO (0.38) | DHFRNPSR1ATMFOLR1ALDH1A1 | |
| SCHEMBL1368290 | 0.74 | NPSR1 (0.50) | MRGPRX4PARP1NPSR1LMNAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415510-A2 | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-03-06 | — | — | EP | disclosed |
| US-4920125-A | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1990-04-24 | — | — | US | disclosed |