Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 3/20 | 0.54 |
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | FNTA | P49354 | 2/20 | 0.46 |
| ▸ | FNTB | P49356 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9850501 | 0.99 | PTAFR (0.53) | PTAFRSETD7CYP2D6CYP2C19SLC6A2 | |
| Hydrochloric Acid SCHEMBL9850772 | 0.92 | PTAFR (0.51) | PTAFRSETD7CYP2D6CYP2C19SLC6A2 | |
| SCHEMBL9850594 | 0.90 | PTAFR (0.57) | PTAFRSETD7CYP2D6CYP2C19SLC6A2 | |
| Hydrochloric Acid SCHEMBL9850511 | 0.89 | PTAFR (0.56) | PTAFRSETD7CYP2D6CYP2C19SLC6A2 | |
| SCHEMBL9850512 | 0.80 | PTAFR (0.61) | PTAFRSETD7CYP2D6CYP2C19SLC6A2 | |
| SCHEMBL9850578 | 0.79 | PTAFR (0.53) | PTAFRSETD7CYP2D6CYP2C19SLC6A2 | |
| SCHEMBL16993485 | 0.75 | SLC6A3 (0.51) | SLC6A2SLC6A3MEN1MAPTKMT2A | |
| SCHEMBL9844293 | 0.75 | CYP3A4 (0.57) | PTAFRSETD7CYP2D6CYP2C19SLC6A2 | |
| Hydrochloric Acid SCHEMBL9844497 | 0.74 | CYP3A4 (0.56) | PTAFRSETD7CYP2D6CYP2C19SLC6A2 | |
| SCHEMBL3721702 | 0.72 | LMNA (0.45) | SLC6A2SLC6A3MAPTSLC6A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0406739-A2 | Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1991-01-09 | — | — | EP | disclosed |