Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19098788 | 0.82 | LMNA (0.54) | KMT2AGLALMNATSHRMEN1 | |
| SCHEMBL30630639 | 0.81 | KMT2A (0.44) | KMT2AGLALMNATSHRMEN1 | |
| SCHEMBL2210341 | 0.81 | CNR2 (0.47) | KMT2AGLAMEN1SMN1; SMN2POLB | |
| SCHEMBL4443917 | 0.81 | CNR2 (0.47) | KMT2AGLAMEN1SMN1; SMN2MAPT | |
| SCHEMBL31336627 | 0.80 | KMT2A (0.48) | KMT2AGLALMNATSHRMEN1 | |
| SCHEMBL982676 | 0.80 | KMT2A (0.57) | KMT2AGLALMNATSHRMEN1 | |
| SCHEMBL982875 | 0.80 | LMNA (0.53) | KMT2AGLALMNATSHRMEN1 | |
| SCHEMBL13836303 | 0.80 | LMNA (0.53) | KMT2AGLALMNATSHRMEN1 | |
| SCHEMBL9948309 | 0.79 | SMN1; SMN2 (0.51) | KMT2ALMNAMEN1SMN1; SMN2MAPT | |
| SCHEMBL1879910 | 0.79 | CNR2 (0.46) | KMT2AGLAMEN1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114672829-A | Method for synthesizing unsaturated ring halide | 凯莱英医药集团（天津）股份有限公司 | 2022-06-28 | — | — | CN | disclosed |
| US-20210101885-A1 | PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | ARENA PHARMACEUTICALS, INC. | 2021-04-08 | — | — | US | disclosed |
| US-10787437-B2 | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor | ARENA PHARMACEUTICALS, INC. (US) | 2020-09-29 | — | — | US | disclosed |
| US-20190023691-A1 | PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | ARENA PHARMACEUTICALS, INC. | 2019-01-24 | — | — | US | disclosed |
| US-10059691-B2 | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor | ARENA PHARMACEUTICALS, INC. (US) | 2018-08-28 | — | — | US | disclosed |
| US-20170137408-A1 | PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | ARENA PHARMACEUTICALS, INC. | 2017-05-18 | — | — | US | disclosed |
| US-9556149-B2 | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor | ARENA PHARMACEUTICALS, INC. (US) | 2017-01-31 | — | — | US | disclosed |
| US-20150045372-A1 | PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | ARENA PHARMACEUTICALS, INC. | 2015-02-12 | — | — | US | disclosed |
| US-20110021538-A1 | PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| WO-2009123714-A2 | PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | ARENA PHARMACEUTICALS, INC. (US) | 2009-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787437-B2 | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor | HTR5A, HTR2A, HTR3A | KMT2A 2827/4885GLA 4719/4885LMNA 4030/4885 |
| US-20150045372-A1 | PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | HTR5A, HTR2A, HTR3A | KMT2A 2827/4885GLA 4719/4885LMNA 4030/4885 |
| US-20170137408-A1 | PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | HTR5A, HTR2A, HTR3A | KMT2A 2827/4885GLA 4719/4885LMNA 4030/4885 |
| US-20210101885-A1 | PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | HTR5A, HTR2A, HTR3A | KMT2A 2827/4885GLA 4719/4885LMNA 4030/4885 |
| US-20190023691-A1 | PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | HTR5A, HTR2A, HTR3A | KMT2A 2827/4885GLA 4719/4885LMNA 4030/4885 |
| US-20110021538-A1 | PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR | HTR5A, HTR2A, HTR3A | KMT2A 2827/4885GLA 4719/4885LMNA 4030/4885 |
| US-10059691-B2 | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor | HTR5A, HTR2A, HTR3A | KMT2A 2827/4885GLA 4719/4885LMNA 4030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.