Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10201451 | 0.68 | DRD2 (0.36) | KDM4EALDH1A1MEN1KMT2APOLB | |
| SCHEMBL15690262 | 0.66 | KDM4E (0.73) | KDM4EALDH1A1MEN1KMT2APOLB | |
| Adipic Acid SCHEMBL166309 | 0.65 | DRD2 (0.60) | KDM4EMEN1KMT2APOLBMAPT | |
| SCHEMBL2944990 | 0.65 | TSHR (0.49) | MEN1KMT2APTGS1PTGS2TSHR | |
| SCHEMBL9151143 | 0.64 | TSHR (0.47) | MEN1KMT2APTGS1PTGS2TSHR | |
| SCHEMBL19513862 | 0.64 | TSHR (0.47) | MEN1KMT2APTGS1PTGS2TSHR | |
| SCHEMBL19513822 | 0.64 | TSHR (0.47) | MEN1KMT2APTGS1PTGS2TSHR | |
| SCHEMBL7416853 | 0.64 | TSHR (0.47) | MEN1KMT2APTGS1PTGS2TSHR | |
| SCHEMBL13593314 | 0.64 | KDM4E (0.78) | KDM4EHPGDALDH1A1HTR1ADRD2 | |
| SCHEMBL3383921 | 0.64 | KDM4E (0.78) | KDM4EHPGDALDH1A1HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416740-A2 | Novel compounds with renin-inhibiting activity | Beecham Group p.l.c. (GB) | 1991-03-13 | — | — | EP | disclosed |