Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 8/20 | 0.60 |
| ▸ | DRD1 | P21728 | 7/20 | 0.60 |
| ▸ | DRD5 | P21918 | 7/20 | 0.60 |
| ▸ | DRD3 | P35462 | 7/20 | 0.60 |
| ▸ | DRD4 | P21917 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL170445 | 0.93 | DRD2 (0.64) | DRD2DRD1DRD5DRD3DRD4 | |
| SCHEMBL17598257 | 0.82 | HDAC3 (0.71) | DRD2DRD3KDM4EHTR1AHTR2A | |
| Adipic Acid SCHEMBL161400 | 0.81 | HTR7 (0.50) | DRD2DRD3KDM4EMEN1POLB | |
| Adipic Acid SCHEMBL160638 | 0.81 | KDM4E (0.46) | DRD2DRD1DRD5DRD3DRD4 | |
| SCHEMBL8687907 | 0.80 | HTR7 (0.76) | DRD2DRD3KDM4EHTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL3887340 | 0.79 | HTR7 (0.74) | DRD2DRD3KDM4EHTR1AHTR2A | |
| SCHEMBL164206 | 0.78 | DRD1 (0.85) | DRD2DRD1DRD5DRD3DRD4 | |
| SCHEMBL29391320 | 0.78 | DRD1 (0.85) | DRD2DRD1DRD5DRD3DRD4 | |
| Fumaric Acid SCHEMBL12467794 | 0.78 | DRD2 (0.59) | DRD2DRD1DRD5DRD3DRD4 | |
| Maleic Acid SCHEMBL167958 | 0.78 | DRD2 (0.59) | DRD2DRD1DRD5DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611449-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030939-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |