Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9586154 | 0.68 | SMN1; SMN2 (0.33) | SMN1; SMN2KDM4EGAAMAPTHPGD | |
| SCHEMBL9099526 | 0.67 | ALDH1A1 (0.35) | ALDH1A1ALOX15MAPK10HSD17B10SMN1; SMN2 | |
| SCHEMBL2827122 | 0.67 | ALDH1A1 (0.38) | ALDH1A1ALOX15MAPK10HSD17B10SMN1; SMN2 | |
| SCHEMBL226035 | 0.66 | GAA (0.41) | ALDH1A1ALOX15GAAMAPTCYP1A2 | |
| SCHEMBL9730822 | 0.66 | ALOX15 (0.36) | ALDH1A1ALOX15MAPK10HSD17B10SMN1; SMN2 | |
| SCHEMBL6787340 | 0.66 | SMN1; SMN2 (0.41) | ALDH1A1ALOX15SMN1; SMN2KDM4EGAA | |
| SCHEMBL31746097 | 0.66 | SMN1; SMN2 (0.41) | ALDH1A1ALOX15SMN1; SMN2KDM4EGAA | |
| Hydrochloric Acid SCHEMBL10718549 | 0.64 | MEN1 (0.39) | ALDH1A1ALOX15GAAMAPTCYP1A2 | |
| SCHEMBL14990432 | 0.63 | — | — | |
| SCHEMBL6642097 | 0.61 | NOS3 (0.30) | ALDH1A1ALOX15MAPK10HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4861878-A | 1H-pyrido-(2,3-b) (1,4)-thiazines | BAYER AKTIENGESELLSCHAFT (DE) | 1989-08-29 | — | — | US | claimed |
| EP-0226023-A1 | 1H-Pyrido-[2,3-b][1,4]-thiazines | BAYER AG (DE) | 1987-06-24 | — | — | EP | claimed |
| JP-62120389-A | — | — | None | — | — | JP | disclosed |
| EP-3004118-B1 | USE OF CONDENSED BENZO[B]THIAZINE DERIVATIVES AS CYTOPROTECTANTS | ARANDA PHARMA LTD (FI) | 2018-12-19 | — | — | EP | disclosed |
| EP-0416740-A2 | Novel compounds with renin-inhibiting activity | Beecham Group p.l.c. (GB) | 1991-03-13 | — | — | EP | disclosed |
| US-4861878-A | 1H-pyrido-(2,3-b) (1,4)-thiazines | BAYER AKTIENGESELLSCHAFT (DE) | 1989-08-29 | — | — | US | disclosed |
| US-4861878-A | 1H-pyrido-(2,3-b) (1,4)-thiazines | BAYER AKTIENGESELLSCHAFT (DE) | 1989-08-29 | — | — | US | disclosed |
| EP-0226023-A1 | 1H-Pyrido-[2,3-b][1,4]-thiazines | BAYER AG (DE) | 1987-06-24 | — | — | EP | disclosed |
| EP-0226023-A1 | 1H-Pyrido-[2,3-b][1,4]-thiazines | BAYER AG (DE) | 1987-06-24 | — | — | EP | disclosed |
| EP-0226023-A1 | 1H-Pyrido-[2,3-b][1,4]-thiazines | BAYER AG (DE) | 1987-06-24 | — | — | EP | disclosed |
| JP-S62120389-A | 1H-PYRIDO-(2,3-B)(1,4)-THIAZINES | BAYER AG | 1987-06-01 | — | — | JP | disclosed |
| EP-0216397-A2 | Process for preparing imidazolinyl compounds | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1987-04-01 | — | — | EP | disclosed |