Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 9/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9850791 | 0.83 | NPSR1 (0.49) | RENKMT2ANPSR1KCNN4KDM4E | |
| SCHEMBL9845852 | 0.77 | NPSR1 (0.41) | RENSCN9ASCN10AKMT2ANPSR1 | |
| SCHEMBL7278305 | 0.73 | HSD17B10 (0.52) | SCN9ASCN10AKMT2AKDM4EALDH1A1 | |
| SCHEMBL7270605 | 0.71 | HSD17B10 (0.46) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL14984829 | 0.64 | ALDH1A1 (0.44) | NPSR1ALDH1A1 | |
| SCHEMBL9850703 | 0.64 | ALDH1A1 (0.46) | KMT2ANPSR1ALDH1A1 | |
| SCHEMBL11327841 | 0.63 | HPGD (0.58) | KMT2AALDH1A1 | |
| SCHEMBL8322503 | 0.62 | KDM4E (0.41) | KDM4EALDH1A1 | |
| SCHEMBL5806069 | 0.62 | MAPT (0.50) | KMT2ANPSR1ALDH1A1 | |
| SCHEMBL14984419 | 0.61 | PLA2G10 (0.37) | SCN9ASCN10AKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416740-A2 | Novel compounds with renin-inhibiting activity | Beecham Group p.l.c. (GB) | 1991-03-13 | — | — | EP | disclosed |