Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9850703 | 0.87 | ALDH1A1 (0.46) | NPSR1USP2SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL9850726 | 0.82 | NPSR1 (0.50) | NPSR1USP2SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL9845834 | 0.79 | NPSR1 (0.53) | NPSR1USP2ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL9845812 | 0.78 | KMT2A (0.47) | NPSR1USP2ALDH1A1LMNAKDM4E | |
| SCHEMBL9850796 | 0.77 | REN (0.34) | NPSR1ALDH1A1SCN9ASCN10AKDM4E | |
| SCHEMBL5806069 | 0.75 | MAPT (0.50) | NPSR1SMN1; SMN2POLBALDH1A1MAPT | |
| SCHEMBL4095906 | 0.73 | ALDH1A1 (0.39) | NPSR1USP2ALDH1A1LMNAMAPT | |
| SCHEMBL19586294 | 0.72 | NPSR1 (0.71) | NPSR1POLBALDH1A1LMNATSHR | |
| SCHEMBL7270855 | 0.70 | MAPT (0.44) | SMN1; SMN2POLBALDH1A1LMNAL3MBTL1 | |
| SCHEMBL7280026 | 0.70 | NPSR1 (0.62) | NPSR1SMN1; SMN2POLBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445467-A1 | Renin inhibitors and antiviral agents | Beecham Group p.l.c. (GB) | 1991-09-11 | — | — | EP | disclosed |
| EP-0416740-A2 | Novel compounds with renin-inhibiting activity | Beecham Group p.l.c. (GB) | 1991-03-13 | — | — | EP | disclosed |