Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 6/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5940440 | 0.76 | NOTUM (0.62) | NOTUMNAMPTLMNAMAPTMEN1 | |
| SCHEMBL5940278 | 0.72 | NOTUM (0.43) | TNFNOTUMNAMPTBRD4HTR2A | |
| Hydrochloric Acid SCHEMBL9094242 | 0.70 | NOTUM (0.39) | TNFNOTUMHSD17B10NAMPTBRD4 | |
| SCHEMBL5940371 | 0.69 | NOTUM (0.56) | NOTUMDRD2MEN1KMT2AALDH1A1 | |
| SCHEMBL8032994 | 0.68 | AOC3 (0.49) | TNFNOTUMHTR1AAOC3 | |
| SCHEMBL19510855 | 0.68 | NOTUM (0.44) | TNFNOTUMBRD4HTR2ALMNA | |
| SCHEMBL1127803 | 0.68 | PAOX (0.59) | HSD17B10NAMPTLMNAMEN1KMT2A | |
| SCHEMBL3003136 | 0.68 | NOS3 (0.46) | HSD17B10BRD4LMNARXFP1MAPT | |
| SCHEMBL6856898 | 0.67 | CYP4F2 (0.43) | TNFNOTUMHSD17B10BRD4LMNA | |
| SCHEMBL7466378 | 0.67 | SMN1; SMN2 (0.50) | TNFHSD17B10FAAHMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416740-A2 | Novel compounds with renin-inhibiting activity | Beecham Group p.l.c. (GB) | 1991-03-13 | — | — | EP | disclosed |