Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM6A | O15550 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM4B | O94953 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1699275 | 0.86 | HPGD (0.49) | ALDH1A1HSD17B10KDM4EHPGDCYP1A2 | |
| SCHEMBL9694050 | 0.80 | LMNA (0.69) | TOP2AALDH1A1KDM4EAURKACYP1A2 | |
| Hydrochloric Acid SCHEMBL9694134 | 0.79 | LMNA (0.67) | TOP2AALDH1A1KDM4EAURKACYP1A2 | |
| SCHEMBL3668564 | 0.79 | TOP2A (0.58) | TOP2AALDH1A1HSD17B10PLAU | |
| SCHEMBL28450779 | 0.77 | TOP2A (0.53) | TOP2AALDH1A1HSD17B10KDM4EAURKA | |
| SCHEMBL1602631 | 0.76 | TOP2A (0.56) | TOP2AALDH1A1KDM4EAURKACYP1A2 | |
| SCHEMBL27502834 | 0.76 | LMNA (0.50) | TOP2AALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL14099640 | 0.76 | ALDH1A1 (0.59) | ALDH1A1HSD17B10KDM4EHPGDPDE5A | |
| SCHEMBL11263883 | 0.75 | ALDH1A1 (0.45) | ALDH1A1HSD17B10KDM4EHPGDMAPT | |
| SCHEMBL10549024 | 0.75 | MAPT (0.49) | TOP2AALDH1A1MAPTMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416740-A2 | Novel compounds with renin-inhibiting activity | Beecham Group p.l.c. (GB) | 1991-03-13 | — | — | EP | disclosed |