Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | GSTP1 | P09211 | 5/20 | 0.40 |
| ▸ | GSTM2 | P28161 | 5/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24477370 | 0.81 | CA2 (0.54) | ALDH1A1MAPTGSTP1GSTM2CA2 | |
| SCHEMBL16702471 | 0.81 | HASPIN (0.45) | ALDH1A1MAPTCA2POLBSMN1; SMN2 | |
| SCHEMBL8941933 | 0.79 | ALDH1A1 (0.67) | ALDH1A1MAPTAPEX1CYP1A2POLB | |
| SCHEMBL16712939 | 0.77 | ALDH1A1 (0.42) | ALDH1A1MAPTPOLBTSHRMAPK1 | |
| SCHEMBL27460398 | 0.77 | ALDH1A1 (0.36) | ALDH1A1MAPTGSTP1GSTM2CA2 | |
| SCHEMBL7919 | 0.76 | SLC22A12 (0.56) | ALDH1A1MAPTSLC22A12APEX1CYP1A2 | |
| SCHEMBL9050843 | 0.75 | MAPT (1.00) | ALDH1A1MAPTAPEX1CA2CYP1A2 | |
| SCHEMBL10681839 | 0.75 | MEN1 (0.56) | ALDH1A1MAPTGSTP1GSTM2CA2 | |
| SCHEMBL1137534 | 0.74 | ALDH1A1 (0.47) | ALDH1A1MAPT | |
| SCHEMBL15801080 | 0.74 | ALDH1A1 (0.72) | ALDH1A1MAPTAPEX1GSTP1GSTM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416740-A2 | Novel compounds with renin-inhibiting activity | Beecham Group p.l.c. (GB) | 1991-03-13 | — | — | EP | disclosed |