SCHEMBL9851152

SCHEMBL9851152

Oc1ccc(Nc2cc(Cl)cc(Cl)c2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.46
CYP3A4 P08684 2/20 0.46
ALOX15 P16050 2/20 0.46
TDP1 Q9NUW8 2/20 0.46
RECQL P46063 2/20 0.46
THRB P10828 1/20 0.46
HIF1A Q16665 1/20 0.46
GAA P10253 6/20 0.44
MAPT P10636 5/20 0.44
ATM Q13315 1/20 0.44
DNM1 Q05193 1/20 0.42
MAPK1 P28482 2/20 0.42
HTT P42858 2/20 0.42
NPSR1 Q6W5P4 2/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
MEN1 O00255 4/20 0.41
KMT2A Q03164 4/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
GSK3B P49841 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11156115 0.83 GSK3B (0.53) ALDH1A1CYP3A4ALOX15TDP1RECQL
SCHEMBL11198333 0.81 TSHR (0.53) ALDH1A1CYP3A4GAAMAPTMAPK1
SCHEMBL17108185 0.80 TTR (0.46) ALDH1A1CYP3A4ALOX15TDP1RECQL
SCHEMBL1921921 0.80 ALDH1A1 (0.57) ALDH1A1CYP3A4ALOX15TDP1RECQL
SCHEMBL1686395 0.80 TSHR (0.57) ALDH1A1CYP3A4GAAMAPTNPSR1
SCHEMBL306231 0.80 ALDH1A1 (0.57) ALDH1A1CYP3A4ALOX15TDP1RECQL
SCHEMBL15400026 0.79 LMNA (0.51) ALOX15RECQLGAAMAPTMAPK1
SCHEMBL13632493 0.78 GAA (0.54) ALDH1A1CYP3A4ALOX15TDP1RECQL
SCHEMBL3170386 0.76 HSD17B10 (0.60) ALDH1A1CYP3A4ALOX15TDP1GAA
SCHEMBL29113772 0.76 HSD17B10 (0.56) ALDH1A1CYP3A4ALOX15TDP1RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0409313-A2 Poly carbonates endowed with high-fluidity characteristics and process for preparing them ENICHEM S.p.A. (IT) 1991-01-23 EP disclosed