SCHEMBL9851153

SCHEMBL9851153

CCOC(=O)CSc1cc(N)ccc1Cl

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.52
HPGD P15428 3/20 0.52
MAPT P10636 3/20 0.52
SHMT2 P34897 1/20 0.52
TSHR P16473 3/20 0.47
HSD17B10 Q99714 2/20 0.47
CYP1A2 P05177 2/20 0.47
CYP3A4 P08684 2/20 0.47
CYP2C9 P11712 1/20 0.47
ALOX15 P16050 1/20 0.47
CYP2C19 P33261 1/20 0.47
KDM4E B2RXH2 3/20 0.47
TP53 P04637 1/20 0.44
HTT P42858 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.43
POLB P06746 1/20 0.43
LMNA P02545 3/20 0.43
ABCB1 P08183 1/20 0.42
TYMS P04818 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8603065 0.78 KDM4E (0.48) ALDH1A1HPGDMAPTSHMT2TSHR
SCHEMBL28463542 0.77 ALDH1A1 (0.58) ALDH1A1HPGDMAPTTSHRHSD17B10
SCHEMBL2300941 0.75 ALDH1A1 (0.52) ALDH1A1HPGDMAPTSHMT2TSHR
SCHEMBL27876705 0.75 TSHR (0.50) ALDH1A1HPGDMAPTSHMT2TSHR
SCHEMBL4277534 0.75 MAOA (0.44) ALDH1A1HPGDMAPTSHMT2TSHR
SCHEMBL3781947 0.74 TSHR (0.46) ALDH1A1HPGDMAPTTSHRHSD17B10
SCHEMBL3535548 0.74 ALDH1A1 (0.47) ALDH1A1HPGDMAPTTSHRHSD17B10
SCHEMBL8870482 0.74 HSD17B10 (0.62) ALDH1A1HPGDMAPTTSHRHSD17B10
SCHEMBL3911561 0.74 ALDH1A1 (0.51) ALDH1A1HPGDMAPTSHMT2TSHR
SCHEMBL23784821 0.73 ALDH1A1 (0.46) ALDH1A1HPGDMAPTTSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0416361-A1 N-(5-alkyl thiophenyl)-nitrogenheterocycles BAYER AG (DE) 1991-03-13 EP disclosed