Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.37 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL1232464 | 1.00 | ALDH1A1 (0.42) | ALDH1A1TSHRKMT2AGAAHTT | |
| Citric Acid SCHEMBL985126 | 1.00 | ALDH1A1 (0.42) | ALDH1A1TSHRKMT2AGAAHTT | |
| SCHEMBL986836 | 0.89 | ALDH1A1 (0.42) | ALDH1A1TSHRKMT2AGAAHTT | |
| Citric Acid SCHEMBL988186 | 0.89 | ALDH1A1 (0.42) | ALDH1A1TSHRKMT2AGAAKDM4E | |
| Citric Acid SCHEMBL988184 | 0.89 | ALDH1A1 (0.42) | ALDH1A1TSHRKMT2AGAAKDM4E | |
| Citric Acid SCHEMBL3802141 | 0.86 | TSHR (0.45) | ALDH1A1TSHRKMT2AGAAKDM4E | |
| Citric Acid SCHEMBL3802147 | 0.86 | TSHR (0.45) | ALDH1A1TSHRKMT2AGAAKDM4E | |
| Citric Acid SCHEMBL3801878 | 0.85 | TSHR (0.44) | ALDH1A1TSHRKMT2AGAAKDM4E | |
| SCHEMBL986292 | 0.84 | TSHR (0.49) | ALDH1A1TSHRKMT2AGAAKDM4E | |
| SCHEMBL987217 | 0.84 | GAA (0.40) | ALDH1A1TSHRKMT2AGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464739-B1 | METHODS IN CELL CULTURES, AND RELATED INVENTIONS, EMPLOYING CERTAIN ADDITIVES | BASF SE (DE) | 2016-01-13 | — | — | EP | claimed |
| US-8859235-B2 | Methods in cell cultures, and related inventions, employing certain additives | BASF SE (DE) | 2014-10-14 | — | — | US | claimed |
| US-20140287250-A1 | COLOR STABILIZATION OF CORK AND COLORED WOODS BY THE COMBINED USE OF INORGANIC AND ORGANIC UV-ABSORBERS | BASF SE (DE) | 2014-09-25 | — | — | US | claimed |
| EP-1896550-B1 | STABILIZED ELECTROCHROMIC MEDIA | BASF SE (DE) | 2013-08-14 | — | — | EP | claimed |
| US-20120328893-A1 | COLOR STABILIZATION OF CORK AND COLORED WOODS BY THE COMBINED USE OF INORGANIC AND ORGANIC UV-ABSORBERS | SCHALLER CHRISTIAN MARCUS (CH) | 2012-12-27 | — | — | US | claimed |
| EP-1680541-B1 | STABILIZED BODY CARE PRODUCTS, HOUSEHOLD PRODUCTS, TEXTILES AND FABRICS | BASF SE (DE) | 2012-12-19 | — | — | EP | claimed |
| US-20120164162-A1 | METHODS IN CELL CULTURES, AND RELATED INVENTIONS, EMPLOYING CERTAIN ADDITIVES | BASF SE (DE) | 2012-06-28 | — | — | US | claimed |
| EP-2464739-A2 | METHODS IN CELL CULTURES, AND RELATED INVENTIONS, EMPLOYING CERTAIN ADDITIVES | BASF SE (DE) | 2012-06-20 | — | — | EP | claimed |
| WO-2011018472-A2 | METHODS IN CELL CULTURES, AND RELATED INVENTIONS, EMPLOYING CERTAIN ADDITIVES | BASF SE (DE) | 2011-02-17 | — | — | WO | claimed |
| US-7862746-B2 | Stabilization of natural composites | BASF SE. (DE) | 2011-01-04 | — | — | US | claimed |
| US-6500303-B1 | DERIVATIVES OF 1-OXYL-2,2,6,6-TETRAMETHYL-PIPERIDIN-4-OL; PROTECTION FROM ULTRAVIOLET, FLUORESCENT AND SUN LIGHT EXPOSURE | CIBA SPECIALTY CHEMICALS CORPORATION | 2002-12-31 | — | — | US | claimed |
| US-20020124980-A1 | Inhibition of pulp and paper yellowing using nitroxides, hydroxylamines and other coadditives | SELTZER RAYMOND R (US) | 2002-09-12 | — | — | US | claimed |
| WO-2002055618-A1 | INK-JET INK AND RECORDING MATERIAL | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2002-07-18 | — | — | WO | claimed |
| EP-1207984-A1 | STABILIZATION OF WOOD SUBSTRATES | Ciba SC Holding AG (CH) | 2002-05-29 | — | — | EP | claimed |
| US-6254724-B1 | STABILIZING AMOUNT OF A HINDERED AMINE COMPOUND SELECTED DERIVATIVES OF 1-OXYL-2,2,6,6-TETRAMETHYL-PIPERIDIN-4-OL OR WHICH ARE THEIR HYDROXYLAMINE SALTS | CIBA SPECIALTY CHEMICALS CORPORATION | 2001-07-03 | — | — | US | claimed |
| WO-2001017738-A1 | STABILIZATION OF WOOD SUBSTRATES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2001-03-15 | — | — | WO | claimed |
| US-6187387-B1 | PROTECTING WOOD AGAINST LIGHT-INDUCED DEGRADATION BY TREATMENT WITH STAIN OR IMPREGNATION WHICH PENETRATES SURFACE OF WOOD COMPRISING HINDETED AMINE COMPOUND AND SOLVENT | CIBA SPECIALTY CHEMICALS CORPORATION | 2001-02-13 | — | — | US | claimed |
| EP-1000032-A1 | INHIBITION OF PULP AND PAPER YELLOWING USING NITROXIDES AND OTHER COADDITIVES | Ciba SC Holding AG (CH) | 2000-05-17 | — | — | EP | claimed |
| EP-0943665-A1 | Stabilization of wood substrates | Ciba SC Holding AG (CH) | 1999-09-22 | — | — | EP | claimed |
| WO-1999005108-A1 | INHIBITION OF PULP AND PAPER YELLOWING USING NITROXIDES AND OTHER COADDITIVES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 1999-02-04 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120164162-A1 | METHODS IN CELL CULTURES, AND RELATED INVENTIONS, EMPLOYING CERTAIN ADDITIVES | BBOX1, NEFM, NQO1 | ESR1 4385/4885MEN1 3694/4885ALDH1A1 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.