Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS2 | Q96GW9 | 4/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10439327 | 0.90 | PARP1 (0.40) | MARS2PRMT5NOS3NOS1NOS2 | |
| SCHEMBL9318815 | 0.86 | GAA (0.47) | MARS2SIRT2ADORA3ADORA2AADORA1 | |
| SCHEMBL17513504 | 0.83 | RAD52 (0.44) | MARS2SIRT2KDM4EPRMT5NOS3 | |
| SCHEMBL9090094 | 0.83 | ADORA1 (0.40) | ADORA3ADORA2AADORA1KDM4ENOS3 | |
| SCHEMBL19378102 | 0.80 | CACNA1H (0.40) | MARS2SIRT2KDM4EPRMT5NOS3 | |
| SCHEMBL19408174 | 0.79 | PRMT5 (0.40) | MARS2SIRT2PRMT5NOS3NOS1 | |
| SCHEMBL9977950 | 0.79 | TDP1 (0.49) | MARS2SIRT2KDM4EPRMT5KMT2A | |
| Hydrochloric Acid SCHEMBL19377908 | 0.77 | PRMT5 (0.39) | MARS2SIRT2KDM4EPRMT5NOS3 | |
| SCHEMBL9851491 | 0.77 | PRMT5 (0.42) | ADORA3ADORA2AADORA1KDM4EPRMT5 | |
| SCHEMBL9851421 | 0.77 | NOS1 (0.60) | SIRT2ADORA3ADORA2AADORA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0434038-A1 | Fused imidazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-06-26 | — | — | EP | disclosed |