Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9705920 | 0.91 | PRMT5 (0.41) | PRMT5NOS1NOS2NOS3KMT2A | |
| SCHEMBL9090094 | 0.77 | ADORA1 (0.40) | ADORA3ADORA2AADORA1KDM4ENOS1 | |
| SCHEMBL9851422 | 0.77 | MARS2 (0.41) | PRMT5ADORA3ADORA2AADORA1KDM4E | |
| SCHEMBL9851421 | 0.74 | NOS1 (0.60) | PRMT5ADORA3ADORA2AADORA1KDM4E | |
| SCHEMBL9851448 | 0.72 | ADORA3 (0.36) | ADORA3ADORA2AADORA1KDM4ENOS1 | |
| SCHEMBL3960231 | 0.70 | CYP2C9 (0.57) | NOS1NOS2CYP2C9 | |
| SCHEMBL10439327 | 0.68 | PARP1 (0.40) | PRMT5NOS1NOS2NOS3KMT2A | |
| SCHEMBL9703975 | 0.68 | PARP1 (0.40) | NOS1NOS2NOS3KMT2APOLB | |
| SCHEMBL9704776 | 0.68 | PI4KA (0.46) | KDM4ENOS1NOS2NOS3KMT2A | |
| SCHEMBL9088551 | 0.67 | HTR1F (0.43) | ADORA3ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0434038-A1 | Fused imidazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-06-26 | — | — | EP | disclosed |