Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
| ▸ | ESRRA | P11474 | 1/20 | 0.37 |
| ▸ | EIF4A1 | P60842 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7576593 | 0.83 | ALDH1A1 (0.42) | PDE5AALDH1A1GAAKDM4EGLA | |
| SCHEMBL9702581 | 0.83 | ALDH1A1 (0.44) | PDE5AALDH1A1GAAKDM4EGLA | |
| SCHEMBL7650243 | 0.82 | ALDH1A1 (0.41) | PDE5AALDH1A1GAAKDM4EGLA | |
| SCHEMBL7376004 | 0.82 | PDE5A (0.50) | PDE5AALDH1A1GAAKDM4EGLA | |
| SCHEMBL7647544 | 0.81 | ALDH1A1 (0.54) | ALDH1A1GAAKDM4EGLAL3MBTL1 | |
| SCHEMBL7648674 | 0.81 | AR (0.40) | PDE5AALDH1A1GAAKDM4EGLA | |
| SCHEMBL7646410 | 0.80 | ALDH1A1 (0.58) | ALDH1A1KMT2AHPGD | |
| SCHEMBL7644788 | 0.79 | PDE5A (0.45) | PDE5AALDH1A1GAAKDM4EGLA | |
| SCHEMBL7648106 | 0.79 | PDE5A (0.43) | PDE5AALDH1A1GAAKDM4EGLA | |
| SCHEMBL10352701 | 0.79 | CYP19A1 (0.55) | PDE5ACYP19A1ALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0428268-A2 | Pharmaceutical phenylpyridone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-05-22 | — | — | EP | claimed |
| EP-0428268-A2 | Pharmaceutical phenylpyridone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-05-22 | — | — | EP | disclosed |