Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.39 |
| ▸ | PTAFR | P25105 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10416860 | 0.89 | BRD4 (0.51) | BRD4GABRA1GABRA5GABRA2GABRA3 | |
| SCHEMBL10416851 | 0.85 | BRD4 (0.40) | BRD4GABRA1GABRA5GABRA2GABRA3 | |
| SCHEMBL10418277 | 0.74 | OPRK1 (0.42) | BRD4GABRA1GABRA5GABRA2GABRA3 | |
| SCHEMBL9851881 | 0.72 | BRD4 (0.42) | BRD4GABRA1GABRA5GABRA2GABRA3 | |
| SCHEMBL9851851 | 0.68 | BRD4 (0.52) | BRD4GABRA1GABRA5GABRA2GABRA3 | |
| SCHEMBL10417388 | 0.65 | KDM4E (0.41) | BRD4GABRA1GABRA5GABRA2GABRA3 | |
| SCHEMBL8274469 | 0.64 | GABRA1 (0.80) | BRD4GABRA1GABRA5GABRA2GABRA3 | |
| SCHEMBL10417392 | 0.64 | GABRA5 (0.52) | BRD4GABRA1GABRA5GABRA2GABRA3 | |
| SCHEMBL16963701 | 0.64 | BRD4 (0.52) | BRD4GABRA1GABRA5GABRA2GABRA3 | |
| SCHEMBL144098 | 0.63 | NTRK1 (0.45) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4897392-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | claimed |
| EP-0406719-A1 | 4h-indolo(1,2-d)(1,2,4)triazolo (4,3-a)(1,4)benzodiazepines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-09 | — | — | EP | disclosed |
| US-4897392-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | disclosed |