Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | PTAFR | P25105 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10416848 | 0.87 | OPRK1 (0.51) | OPRK1PDE4DHPGDGABRG2GABRB3 | |
| SCHEMBL9851881 | 0.75 | BRD4 (0.42) | OPRK1PDE4DALDH1A1KMT2AKDM4E | |
| SCHEMBL10418270 | 0.70 | OPRK1 (0.44) | OPRK1ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL2421457 | 0.69 | KDM4E (0.49) | ALDH1A1KMT2AKDM4EMEN1MAPT | |
| SCHEMBL11411752 | 0.65 | CA12 (0.42) | OPRK1PDE4DALDH1A1CYP11B2CYP11B1 | |
| SCHEMBL9851803 | 0.64 | CREBBP (0.39) | ALDH1A1KMT2AKDM4EMEN1MAPT | |
| SCHEMBL9851851 | 0.64 | BRD4 (0.52) | OPRK1PDE4DALDH1A1HPGDGABRG2 | |
| SCHEMBL10417392 | 0.64 | GABRA5 (0.52) | OPRK1PDE4DHPGDGABRG2GABRB3 | |
| SCHEMBL11402921 | 0.63 | OPRK1 (0.50) | OPRK1PDE4DALDH1A1ADRA2ACYP11B2 | |
| SCHEMBL10417388 | 0.62 | KDM4E (0.41) | OPRK1PDE4DALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0406719-A1 | 4h-indolo(1,2-d)(1,2,4)triazolo (4,3-a)(1,4)benzodiazepines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-09 | — | — | EP | disclosed |
| US-4897392-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | disclosed |