Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 9/20 | 0.40 |
| ▸ | CDK1 | P06493 | 9/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 9/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 9/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10416854 | 0.87 | CNR1 (0.46) | GSK3BCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL9851860 | 0.83 | CDK1 (0.44) | GSK3BCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL9851806 | 0.83 | HTR2A (0.40) | GSK3BCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL5256403 | 0.78 | OPRM1 (0.39) | GSK3BCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL4135918 | 0.69 | CREBBP (0.46) | GSK3BCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL10923868 | 0.69 | TOP2A (0.49) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL31289276 | 0.69 | TOP2A (0.49) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL9851805 | 0.64 | CNR1 (0.44) | LRRK2CREBBPMEN1KMT2A | |
| SCHEMBL9231144 | 0.63 | AHR (0.53) | GSK3BCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL6399576 | 0.63 | EPHX2 (0.44) | GSK3BCCNB2CDK1CCNB1CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0406719-A1 | 4h-indolo(1,2-d)(1,2,4)triazolo (4,3-a)(1,4)benzodiazepines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-09 | — | — | EP | disclosed |
| US-4914201-A | CHEMICAL INTERMEDIATES FOR ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-04-03 | — | — | US | disclosed |
| US-4897392-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | disclosed |