Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 2/20 | 0.43 |
| ▸ | GABRD | O14764 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.43 |
| ▸ | GABRE | P78334 | 2/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4135918 | 0.85 | CREBBP (0.46) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9851810 | 0.85 | CHRM1 (0.44) | CNR1NTSR1OPRK1PDE4DTGM2 | |
| SCHEMBL20777927 | 0.76 | PIM1 (0.39) | KMT2ABRD4CREBBP | |
| SCHEMBL10416854 | 0.76 | CNR1 (0.46) | CNR1NTSR1OPRK1PDE4DGABRP | |
| SCHEMBL9851803 | 0.69 | CREBBP (0.39) | MEN1KMT2ABRD4CREBBPMAPT | |
| SCHEMBL11704524 | 0.68 | LRRK2 (0.44) | CNR1NTSR1OPRK1PDE4DGABRP | |
| SCHEMBL2850811 | 0.68 | MEN1 (0.68) | CNR1NTSR1OPRK1PDE4DGABRP | |
| SCHEMBL17522841 | 0.68 | PIK3CA (0.41) | DRD3MAPT | |
| SCHEMBL10416848 | 0.66 | OPRK1 (0.51) | CNR1OPRK1PDE4DGABRA1GABRG2 | |
| SCHEMBL3579839 | 0.66 | CNR1 (0.52) | CNR1NTSR1OPRK1PDE4DGABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0406719-A1 | 4h-indolo(1,2-d)(1,2,4)triazolo (4,3-a)(1,4)benzodiazepines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-09 | — | — | EP | disclosed |
| US-4914201-A | CHEMICAL INTERMEDIATES FOR ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-04-03 | — | — | US | disclosed |
| US-4897392-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | disclosed |