Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 3/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | CAMKK2 | Q96RR4 | 4/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL979102 | 0.84 | MEN1 (0.33) | PARP1DHODHPARP2SYKNTRK1 | |
| SCHEMBL986588 | 0.82 | CSNK1A1 (0.46) | PARP1DHODHPARP2GRM5CDC7 | |
| SCHEMBL986590 | 0.80 | CSNK1A1 (0.47) | PARP1DHODHPARP2GRM5CDC7 | |
| SCHEMBL17386563 | 0.80 | PARP1 (0.45) | PARP1DHODHPARP2SYKNTRK1 | |
| SCHEMBL977785 | 0.79 | PDK2 (0.34) | PARP1DHODHPARP2SYKNTRK1 | |
| SCHEMBL15410051 | 0.76 | SQOR (0.33) | PARP1DHODHPARP2TGFBR1 | |
| SCHEMBL20544704 | 0.75 | BTK (0.44) | PARP1DHODHPARP2NTRK1GRM5 | |
| SCHEMBL978876 | 0.72 | IKBKB (0.33) | SYKCAMKK2BTK | |
| SCHEMBL2943452 | 0.69 | GRM5 (0.54) | PARP1DHODHPARP2GRM5CDC7 | |
| SCHEMBL3978369 | 0.69 | KDM4E (0.43) | DHODHALDH1A1PDK2PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009410-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009410-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | BAX, CASP1, AIFM1 | PARP1 578/4885DHODH 4761/4885PARP2 1172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.