Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9852290 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2L3MBTL1NPC1RAB9ALMNA | |
| SCHEMBL3759738 | 0.85 | GRM1 (0.49) | SMN1; SMN2L3MBTL1NPC1RAB9ALMNA | |
| SCHEMBL24491092 | 0.81 | GRM1 (0.43) | SMN1; SMN2L3MBTL1NPC1RAB9ALMNA | |
| SCHEMBL24491053 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2L3MBTL1NPC1RAB9ALMNA | |
| SCHEMBL24491070 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2L3MBTL1NPC1RAB9ALMNA | |
| SCHEMBL24491025 | 0.79 | RAB9A (0.56) | SMN1; SMN2L3MBTL1NPC1RAB9ALMNA | |
| SCHEMBL1855039 | 0.79 | RAB9A (0.58) | SMN1; SMN2NPC1RAB9ALMNAKMT2A | |
| SCHEMBL16254891 | 0.75 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1NPC1RAB9ALMNA | |
| SCHEMBL9892988 | 0.75 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1NPC1RAB9ALMNA | |
| SCHEMBL9852268 | 0.75 | NPC1 (0.53) | SMN1; SMN2L3MBTL1NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022117075-A1 | AZACYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 广州费米子科技有限责任公司 | 2022-06-09 | — | — | WO | disclosed |
| EP-0455356-A1 | Substituted 5-amino-1,2,4-thiadiazoles with pharmaceutical activity | LILLY INDUSTRIES LIMITED (GB) | 1991-11-06 | — | — | EP | disclosed |