Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4499496 | 0.87 | NPC1 (0.43) | NPC1SMN1; SMN2RAB9APOLBLMNA | |
| SCHEMBL24951752 | 0.84 | ALDH1A1 (0.62) | NPC1SMN1; SMN2RAB9ALMNAKMT2A | |
| SCHEMBL24491068 | 0.83 | RAB9A (0.58) | NPC1SMN1; SMN2RAB9APOLBLMNA | |
| SCHEMBL8573205 | 0.82 | ALDH1A1 (0.50) | NPC1SMN1; SMN2RAB9APOLBLMNA | |
| SCHEMBL8569667 | 0.81 | SMN1; SMN2 (0.46) | NPC1SMN1; SMN2RAB9APOLBLMNA | |
| SCHEMBL24952058 | 0.80 | SMN1; SMN2 (0.44) | NPC1SMN1; SMN2RAB9APOLBLMNA | |
| SCHEMBL27944608 | 0.80 | ALDH1A1 (0.48) | NPC1SMN1; SMN2RAB9APOLBLMNA | |
| SCHEMBL16192288 | 0.78 | ALDH1A1 (0.38) | NPC1SMN1; SMN2RAB9APOLBLMNA | |
| SCHEMBL24491045 | 0.75 | SMN1; SMN2 (0.41) | NPC1SMN1; SMN2RAB9APOLBLMNA | |
| SCHEMBL24491070 | 0.75 | SMN1; SMN2 (0.53) | NPC1SMN1; SMN2RAB9APOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0455356-A1 | Substituted 5-amino-1,2,4-thiadiazoles with pharmaceutical activity | LILLY INDUSTRIES LIMITED (GB) | 1991-11-06 | — | — | EP | disclosed |