Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.43 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.43 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9852284 | 0.85 | SMN1; SMN2 (0.53) | SMN1; SMN2L3MBTL1NPC1RAB9ALMNA | |
| SCHEMBL16254958 | 0.75 | SMN1; SMN2 (1.00) | SMN1; SMN2L3MBTL1NPC1RAB9ALMNA | |
| SCHEMBL31665226 | 0.74 | ALDH1A1 (0.51) | SMN1; SMN2L3MBTL1NPC1RAB9ALMNA | |
| SCHEMBL3759738 | 0.73 | GRM1 (0.49) | SMN1; SMN2L3MBTL1NPC1RAB9ALMNA | |
| SCHEMBL1377141 | 0.72 | ADORA3 (0.68) | SMN1; SMN2L3MBTL1NPC1RAB9ALMNA | |
| SCHEMBL6977028 | 0.71 | PRKACA (0.51) | SMN1; SMN2L3MBTL1NPC1RAB9ALMNA | |
| SCHEMBL24491092 | 0.69 | GRM1 (0.43) | SMN1; SMN2L3MBTL1NPC1RAB9ALMNA | |
| SCHEMBL7397370 | 0.69 | KDM4E (0.49) | SMN1; SMN2L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL9852280 | 0.69 | ALDH1A1 (0.69) | SMN1; SMN2NPC1RAB9ALMNAMEN1 | |
| SCHEMBL30058875 | 0.68 | ABL1 (0.72) | SMN1; SMN2L3MBTL1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0455356-A1 | Substituted 5-amino-1,2,4-thiadiazoles with pharmaceutical activity | LILLY INDUSTRIES LIMITED (GB) | 1991-11-06 | — | — | EP | disclosed |