Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | OXTR | P30559 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | HTR5A | P47898 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9853234 | 0.88 | GAA (0.54) | GAANPSR1MAPTKMT2AMEN1 | |
| Maleic Acid SCHEMBL9853230 | 0.88 | GAA (0.54) | GAANPSR1MAPTKMT2AMEN1 | |
| SCHEMBL1368071 | 0.82 | GAA (1.00) | GAANPSR1MAPTKMT2AMEN1 | |
| SCHEMBL14808600 | 0.75 | MAOB (0.65) | GAANPSR1KMT2AMEN1MAOA | |
| Iodide SCHEMBL30281983 | 0.74 | MAOB (0.63) | GAANPSR1KMT2AMEN1MAOA | |
| SCHEMBL8556344 | 0.72 | NPSR1 (0.67) | GAANPSR1MAPTKMT2AMEN1 | |
| SCHEMBL19810681 | 0.72 | MAOA (0.48) | GAANPSR1MAOAMAOBSMN1; SMN2 | |
| SCHEMBL8515984 | 0.72 | MAOB (0.65) | GAANPSR1KMT2AMEN1MAOA | |
| SCHEMBL10593558 | 0.70 | ALOX15 (0.66) | GAANPSR1MAPTALOX15HSD17B10 | |
| SCHEMBL30704654 | 0.70 | CA12 (0.46) | GAANPSR1MAPTMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4940704-A | Pyrido[3,4-b][1,4]benzoxazepines | HOECHST-ROUSSEL PHARMACEUTICAL INC. (US) | 1990-07-10 | — | — | US | claimed |
| EP-0413300-A1 | Pyrido [3,4-b][1,4] benzoxazepines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-02-20 | — | — | EP | disclosed |
| US-4940704-A | Pyrido[3,4-b][1,4]benzoxazepines | HOECHST-ROUSSEL PHARMACEUTICAL INC. (US) | 1990-07-10 | — | — | US | disclosed |