Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | PRKACA | P17612 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 4/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 2/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8134709 | 0.81 | MAPT (0.49) | CES1NSD2BCHEDAOAHR | |
| SCHEMBL9853252 | 0.79 | MAPT (0.45) | CDC7ROCK2MAP4K4PRKACACDK2 | |
| SCHEMBL1367572 | 0.70 | MAPT (0.51) | CDC7ROCK2MAP4K4PRKACACDK2 | |
| SCHEMBL12367150 | 0.69 | CDK2 (0.43) | CDC7ROCK2MAP4K4PRKACACDK2 | |
| SCHEMBL9853272 | 0.69 | MAPT (0.48) | CDC7ROCK2MAP4K4PRKACACDK2 | |
| SCHEMBL30595249 | 0.65 | LMNA (0.52) | CDK2GSK3BTGM2CES1AHR | |
| SCHEMBL2509785 | 0.64 | ACVR1 (0.69) | CDC7ROCK2MAP4K4PRKACACDK2 | |
| SCHEMBL8136244 | 0.64 | MEN1 (0.54) | GSK3BCHEK1MAPTTP53LMNA | |
| SCHEMBL5357237 | 0.64 | MAPT (0.45) | GSK3BCHEK1MAPTTP53LMNA | |
| SCHEMBL9174571 | 0.63 | ACVR1 (0.62) | CDC7ROCK2MAP4K4PRKACACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0413300-A1 | Pyrido [3,4-b][1,4] benzoxazepines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-02-20 | — | — | EP | disclosed |
| US-4940704-A | Pyrido[3,4-b][1,4]benzoxazepines | HOECHST-ROUSSEL PHARMACEUTICAL INC. (US) | 1990-07-10 | — | — | US | disclosed |