Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | STK17B | O94768 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FER | P16591 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1367572 | 0.88 | MAPT (0.51) | MAPTTDP1L3MBTL1MEN1KMT2A | |
| SCHEMBL380110 | 0.81 | ALOX5 (0.61) | MAPTTDP1L3MBTL1MEN1KMT2A | |
| SCHEMBL9853272 | 0.80 | MAPT (0.48) | MAPTTDP1L3MBTL1MEN1KMT2A | |
| SCHEMBL9853247 | 0.79 | CDC7 (0.41) | MAPTLMNATP53MAPK1HTT | |
| SCHEMBL12367150 | 0.75 | CDK2 (0.43) | MAPTMEN1KMT2ASTK17BCDK8 | |
| SCHEMBL17059744 | 0.73 | LMNA (0.46) | MAPTTDP1L3MBTL1MEN1KMT2A | |
| SCHEMBL2509785 | 0.72 | ACVR1 (0.69) | MAPTL3MBTL1ALDH1A1KDM4EPDGFRA | |
| SCHEMBL7336729 | 0.72 | CYP1A2 (0.55) | MAPTTDP1L3MBTL1MEN1KMT2A | |
| SCHEMBL1366565 | 0.72 | LMNA (0.58) | MAPTTDP1L3MBTL1MEN1KMT2A | |
| SCHEMBL17988251 | 0.72 | MAPT (0.48) | MAPTTDP1L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0413300-A1 | Pyrido [3,4-b][1,4] benzoxazepines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-02-20 | — | — | EP | disclosed |
| US-4940704-A | Pyrido[3,4-b][1,4]benzoxazepines | HOECHST-ROUSSEL PHARMACEUTICAL INC. (US) | 1990-07-10 | — | — | US | disclosed |