Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 2/20 | 0.69 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.69 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.69 |
| ▸ | FER | P16591 | 1/20 | 0.69 |
| ▸ | LTK | P29376 | 1/20 | 0.69 |
| ▸ | CDK8 | P49336 | 1/20 | 0.69 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.69 |
| ▸ | CDK2 | P24941 | 5/20 | 0.56 |
| ▸ | GSK3B | P49841 | 5/20 | 0.56 |
| ▸ | CDC7 | O00311 | 4/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.56 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.56 |
| ▸ | PRKACA | P17612 | 3/20 | 0.56 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.56 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9174571 | 0.89 | ACVR1 (0.62) | ACVR1LRRK2PDGFRAFERLTK | |
| SCHEMBL31050976 | 0.83 | MAPT (0.59) | ACVR1LRRK2PDGFRAFERLTK | |
| SCHEMBL1368292 | 0.83 | LRRK2 (1.00) | ACVR1LRRK2PDGFRAFERLTK | |
| Hydrochloric Acid SCHEMBL6299954 | 0.81 | LRRK2 (0.95) | ACVR1LRRK2PDGFRAFERLTK | |
| SCHEMBL2420711 | 0.79 | LRRK2 (0.90) | ACVR1LRRK2PDGFRAFERLTK | |
| SCHEMBL366728 | 0.79 | — | — | |
| SCHEMBL27980501 | 0.75 | LRRK2 (0.82) | ACVR1LRRK2PDGFRAFERLTK | |
| SCHEMBL20875235 | 0.73 | PDGFRA (0.55) | ACVR1LRRK2PDGFRAFERLTK | |
| SCHEMBL9853252 | 0.72 | MAPT (0.45) | ACVR1LRRK2PDGFRAFERLTK | |
| SCHEMBL17059930 | 0.72 | CHEK1 (0.60) | ACVR1LRRK2PDGFRAFERLTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8541407-B2 | Substituted benzo-pyrido-triazolo-diazepine compounds | ARQULE, INC. (US) | 2013-09-24 | — | — | US | disclosed |
| US-8541407-B2 | Substituted benzo-pyrido-triazolo-diazepine compounds | ARQULE, INC. (US) | 2013-09-24 | — | — | US | disclosed |
| WO-2011123678-A2 | SUBSTITUTED BENZO-PYRIDO-TRIAZOLO-DIAZEPINE COMPOUNDS | ARQULE, INC. (US) | 2011-10-06 | — | — | WO | disclosed |
| US-20110245236-A1 | Substituted Benzo-Pyrido-Triazolo-Diazepine Compounds | ARQULE, INC. (US) | 2011-10-06 | — | — | US | disclosed |
| US-20110245236-A1 | Substituted Benzo-Pyrido-Triazolo-Diazepine Compounds | ARQULE, INC. (US) | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245236-A1 | Substituted Benzo-Pyrido-Triazolo-Diazepine Compounds | BRD4, PDXK, THPO | ACVR1 3447/4885LRRK2 2277/4885PDGFRA 372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.