Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.51 |
| ▸ | HRH1 | P35367 | 5/20 | 0.51 |
| ▸ | DRD2 | P14416 | 4/20 | 0.51 |
| ▸ | HTR6 | P50406 | 4/20 | 0.51 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.51 |
| ▸ | DRD1 | P21728 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | HEXA | P06865 | 1/20 | 0.44 |
| ▸ | HEXB | P07686 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10475573 | 0.93 | SLC6A4 (0.56) | SLC6A4HRH1DRD2HTR6HTR1A | |
| Hydrochloric Acid SCHEMBL10475278 | 0.92 | SLC6A4 (0.55) | SLC6A4HRH1DRD2HTR6HTR1A | |
| SCHEMBL9853218 | 0.79 | NR1H2 (0.50) | HDAC3TUBB4ATUBBTUBA3CHDAC4 | |
| Hydrochloric Acid SCHEMBL9853274 | 0.78 | NR1H2 (0.49) | HDAC3TUBB4ATUBBTUBA3CHDAC4 | |
| SCHEMBL9853284 | 0.78 | MAOA (0.48) | HDAC3TUBB4ATUBBTUBA3CHDAC4 | |
| Hydrochloric Acid SCHEMBL9853219 | 0.77 | MAOA (0.47) | HDAC3TUBB4ATUBBTUBA3CHDAC4 | |
| Hydrochloric Acid SCHEMBL9853244 | 0.72 | ALDH1A1 (0.46) | CHRM2LMNAHDAC3TUBB4ATUBB | |
| SCHEMBL30718464 | 0.71 | KDM1A (0.59) | SLC6A4HRH1DRD2HTR6HTR1A | |
| SCHEMBL29277400 | 0.71 | KDM1A (0.59) | SLC6A4HRH1DRD2HTR6HTR1A | |
| SCHEMBL30839875 | 0.71 | HEXA (0.72) | SLC6A4HRH1DRD2HTR6HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4940704-A | Pyrido[3,4-b][1,4]benzoxazepines | HOECHST-ROUSSEL PHARMACEUTICAL INC. (US) | 1990-07-10 | — | — | US | claimed |
| EP-0413300-A1 | Pyrido [3,4-b][1,4] benzoxazepines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-02-20 | — | — | EP | disclosed |
| US-4940704-A | Pyrido[3,4-b][1,4]benzoxazepines | HOECHST-ROUSSEL PHARMACEUTICAL INC. (US) | 1990-07-10 | — | — | US | disclosed |