Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 5/20 | 0.34 |
| ▸ | RXRB | P28702 | 4/20 | 0.34 |
| ▸ | RXRG | P48443 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9853578 | 0.77 | SMN1; SMN2 (0.41) | MAPTLMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL9853588 | 0.74 | PIN1 (0.49) | MAPTLMNAL3MBTL1HPGDMEN1 | |
| SCHEMBL11547238 | 0.74 | HPGD (0.68) | MAPTLMNAL3MBTL1HPGDMEN1 | |
| SCHEMBL31312989 | 0.73 | BCL2L1 (0.54) | RXRARXRBRXRGSMN1; SMN2 | |
| SCHEMBL4377981 | 0.72 | MEN1 (0.48) | MAPTLMNAL3MBTL1HPGDMEN1 | |
| SCHEMBL10963407 | 0.71 | HSPB1 (0.47) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL6688479 | 0.70 | MAPT (0.51) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL31180267 | 0.70 | MAPT (0.51) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL11110730 | 0.69 | MEN1 (0.46) | MAPTLMNAHPGDMEN1KMT2A | |
| SCHEMBL11030951 | 0.69 | KMT2A (0.54) | MAPTLMNAL3MBTL1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4931457-A | Naphthylamino-and naphthyloxy-pyridinamine comounds useful as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-05 | — | — | US | claimed |
| EP-0405426-A2 | Naphthylamino- and naphthyloxy-pyridinamines and related compounds, a process for their preparation and their use as dermatological agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-02 | — | — | EP | disclosed |
| US-4931457-A | Naphthylamino-and naphthyloxy-pyridinamine comounds useful as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-05 | — | — | US | disclosed |