Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9853579 | 0.78 | PIN1 (0.47) | SMN1; SMN2HTTRAB9ANPC1LMNA | |
| SCHEMBL9853598 | 0.77 | MAPT (0.36) | SMN1; SMN2CYP3A4RAB9ANPC1ALOX15 | |
| SCHEMBL9853587 | 0.76 | ALDH1A1 (0.37) | SMN1; SMN2HTTPTPN1LMNAMAPT | |
| SCHEMBL7055435 | 0.76 | ALDH1A1 (0.45) | SMN1; SMN2CYP3A4HTTTSHRHSD17B10 | |
| SCHEMBL9853789 | 0.76 | MERTK (0.48) | SMN1; SMN2HTTRAB9ANPC1MAPK1 | |
| SCHEMBL4375480 | 0.76 | PDE7A (0.49) | SMN1; SMN2TSHRMAPK1LMNAMAPT | |
| SCHEMBL4376514 | 0.76 | LMNA (0.42) | SMN1; SMN2HTTRAB9ANPC1PTPN1 | |
| SCHEMBL4377981 | 0.76 | MEN1 (0.48) | SMN1; SMN2CYP3A4CYP2C19RAB9ANPC1 | |
| SCHEMBL13150440 | 0.75 | MEN1 (0.60) | HTTPTPN1MAPK1LMNAMAPT | |
| SCHEMBL4383031 | 0.75 | EPAS1 (0.44) | TSHRMAPK1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4931457-A | Naphthylamino-and naphthyloxy-pyridinamine comounds useful as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-05 | — | — | US | claimed |
| EP-0405426-A2 | Naphthylamino- and naphthyloxy-pyridinamines and related compounds, a process for their preparation and their use as dermatological agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-02 | — | — | EP | disclosed |
| US-4931457-A | Naphthylamino-and naphthyloxy-pyridinamine comounds useful as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-05 | — | — | US | disclosed |