Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 5/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.44 |
| ▸ | ESRRA | P11474 | 4/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9853597 | 0.75 | ESRRA (0.43) | ESRRACCR2TSHRNPC1RAB9A | |
| SCHEMBL9853596 | 0.73 | GAA (0.49) | PTGS1PTGS2ESRRATSHRNPC1 | |
| SCHEMBL9853609 | 0.67 | ALDH1A1 (0.50) | ESRRALMNAMAPTHSP90AA1CCR6 | |
| SCHEMBL10990381 | 0.61 | LMNA (0.46) | ESRRANPC1RAB9ALMNAMAPT | |
| SCHEMBL11544742 | 0.61 | PTGS1 (0.60) | PTGS1PTGS2NPC1RAB9ALMNA | |
| SCHEMBL11750981 | 0.60 | TSHR (0.68) | PTGS1PTGS2ESRRATSHRNPC1 | |
| SCHEMBL10994648 | 0.60 | MAPT (0.48) | ESRRANPC1RAB9ALMNAMAPT | |
| SCHEMBL9188264 | 0.60 | CYP1A2 (0.59) | ESRRATSHRNPC1RAB9ALMNA | |
| SCHEMBL9813739 | 0.60 | TSHR (0.67) | PTGS1ESRRATSHRNPC1RAB9A | |
| SCHEMBL10991633 | 0.60 | LMNA (0.44) | ESRRATSHRNPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0405426-A2 | Naphthylamino- and naphthyloxy-pyridinamines and related compounds, a process for their preparation and their use as dermatological agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-02 | — | — | EP | disclosed |
| US-4931457-A | Naphthylamino-and naphthyloxy-pyridinamine comounds useful as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-05 | — | — | US | disclosed |