Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | ESRRA | P11474 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11477740 | 0.80 | TDP1 (0.53) | ALDH1A1SMN1; SMN2LMNATDP1CYP19A1 | |
| SCHEMBL9853596 | 0.75 | GAA (0.49) | ALDH1A1LMNATDP1ESRRAMAPT | |
| SCHEMBL10544257 | 0.73 | LMNA (0.50) | ALDH1A1SMN1; SMN2LMNATDP1CYP19A1 | |
| SCHEMBL4796250 | 0.73 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2LMNATDP1CYP19A1 | |
| SCHEMBL5593294 | 0.73 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2LMNATDP1CYP19A1 | |
| SCHEMBL30222343 | 0.73 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2LMNATDP1CYP19A1 | |
| SCHEMBL4034382 | 0.73 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2LMNATDP1CYP19A1 | |
| SCHEMBL676142 | 0.72 | LMNA (0.82) | ALDH1A1SMN1; SMN2LMNATDP1CYP19A1 | |
| SCHEMBL30535283 | 0.72 | LMNA (0.82) | ALDH1A1SMN1; SMN2LMNATDP1CYP19A1 | |
| SCHEMBL10964527 | 0.71 | ESRRA (0.56) | ALDH1A1SMN1; SMN2LMNATDP1ESRRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0405426-A2 | Naphthylamino- and naphthyloxy-pyridinamines and related compounds, a process for their preparation and their use as dermatological agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-02 | — | — | EP | claimed |