Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26306447 | 0.83 | TDP1 (0.58) | TDP1POLBMAPTMAPK1LMNA | |
| SCHEMBL9853809 | 0.83 | KMT2A (0.50) | TDP1POLBMAPTLMNASMN1; SMN2 | |
| SCHEMBL31098230 | 0.83 | TDP1 (0.58) | TDP1POLBMAPTMAPK1LMNA | |
| SCHEMBL27002380 | 0.79 | MAPT (0.47) | TDP1POLBMAPTMAPK1LMNA | |
| SCHEMBL31098218 | 0.79 | TDP1 (0.56) | TDP1POLBMAPTLMNASMN1; SMN2 | |
| SCHEMBL4637188 | 0.76 | TDP1 (0.58) | TDP1POLBMAPTKCNMA1LMNA | |
| SCHEMBL1367920 | 0.76 | TDP1 (0.58) | TDP1POLBMAPTKCNMA1LMNA | |
| SCHEMBL31549875 | 0.76 | TDP1 (0.70) | TDP1MAPTMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL40265 | 0.76 | TDP1 (0.70) | TDP1MAPTMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL5373256 | 0.75 | PABPC1 (0.57) | TDP1POLBMAPTMAPK1KCNMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4959377-A | Phenoxypyridinamine compounds which are use as a dermatological composition | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-09-25 | — | — | US | claimed |
| EP-0405487-A1 | Phenoxypyridinamines and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-02 | — | — | EP | disclosed |
| US-4959377-A | Phenoxypyridinamine compounds which are use as a dermatological composition | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-09-25 | — | — | US | disclosed |