Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 8/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9853805 | 0.99 | PTGS1 (0.60) | PTGS1PTGS2TSHRALDH1A1MAPK1 | |
| SCHEMBL2342698 | 0.81 | ADRA2C (0.64) | TSHRALDH1A1MAPK1HSD17B10LMNA | |
| SCHEMBL30327328 | 0.81 | ADRA2C (0.64) | TSHRALDH1A1MAPK1HSD17B10LMNA | |
| SCHEMBL19127754 | 0.80 | ALDH1A1 (0.49) | TSHRALDH1A1MAPTPOLB | |
| SCHEMBL27952758 | 0.77 | KMT2A (0.50) | ALDH1A1MAPK1HSD17B10LMNAMAPT | |
| SCHEMBL26802311 | 0.77 | DYRK1A (0.43) | TSHRALDH1A1HSD17B10MAPT | |
| SCHEMBL11544971 | 0.75 | PTGS1 (0.60) | PTGS1PTGS2TSHRALDH1A1MAPK1 | |
| SCHEMBL23012320 | 0.75 | TDP1 (0.55) | PTGS1PTGS2TSHRALDH1A1MAPK1 | |
| SCHEMBL15890250 | 0.74 | KMT2A (0.53) | PTGS1PTGS2TSHRALDH1A1MAPT | |
| SCHEMBL4139383 | 0.74 | ALDH1A1 (0.55) | TSHRALDH1A1KDM4CRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4959377-A | Phenoxypyridinamine compounds which are use as a dermatological composition | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-09-25 | — | — | US | claimed |
| EP-0405487-A1 | Phenoxypyridinamines and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-02 | — | — | EP | disclosed |
| US-4959377-A | Phenoxypyridinamine compounds which are use as a dermatological composition | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-09-25 | — | — | US | disclosed |