SCHEMBL9854342

SCHEMBL9854342

FC(F)(F)C(F)(F)C(F)(F)C(F)(F)CC(I)Cc1ccccc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 2/20 0.35
CPA1 P15085 3/20 0.35
TAAR1 Q96RJ0 4/20 0.33
SLC6A2 P23975 2/20 0.33
SIGMAR1 Q99720 2/20 0.33
MAOA P21397 1/20 0.33
SLC6A4 P31645 1/20 0.33
SLC6A3 Q01959 1/20 0.33
CYP2A6 P11509 1/20 0.33
ADORA2A P29274 1/20 0.33
ADORA1 P30542 1/20 0.33
CPB1 P15086 1/20 0.33
CPA3 P15088 1/20 0.33
CPB2 Q96IY4 1/20 0.33
CYP1A2 P05177 1/20 0.32
SLC18A2 Q05940 1/20 0.32
ANPEP P15144 1/20 0.32
CYP2D6 P10635 1/20 0.32
ACE P12821 1/20 0.31
ECE1 P42892 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10731618 0.98 EPHX1 (0.34) EPHX1CPA1TAAR1SLC6A2SIGMAR1
SCHEMBL31152018 0.80 SLC6A4 (0.42) SLC6A4CYP1A2CYP2D6
SCHEMBL15346933 0.80 EPHX1 (0.41) EPHX1CPA1TAAR1SLC6A2SIGMAR1
SCHEMBL9854300 0.78 EPHX1 (0.34) EPHX1CPA1TAAR1SLC6A2SIGMAR1
SCHEMBL31433296 0.77 MTNR1A (0.39) EPHX1CPA1SLC6A2SIGMAR1SLC6A4
SCHEMBL29173885 0.74 CPA1 (0.35) EPHX1CPA1TAAR1SLC6A2SIGMAR1
SCHEMBL10489340 0.74 CYP1A2 (0.56) CPA1CPB1CPA3CPB2CYP1A2
SCHEMBL28018404 0.72 LMNA (0.33)
SCHEMBL10737168 0.72 EPHX1 (0.55) EPHX1TAAR1SLC6A2SIGMAR1MAOA
SCHEMBL18918251 0.71 HTR2A (0.37) TAAR1SLC6A3CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115710157-B Fluorine-containing compound initiated by hindered free radical pair, and preparation method and application thereof 吉林大学 2024-10-18 CN disclosed
EP-0252736-B1 PROCESS FOR PREPARING FLUORINE-CONTAINING CARBOXYLIC ACID ESTER SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-07-24 EP disclosed
US-4855487-A Process for preparing fluorine-containing carboxylic acid ester SAGAMI CHEMICAL RESEARCH CENTER (JP) 1989-08-08 US disclosed
EP-0252736-A2 Process for preparing fluorine-containing carboxylic acid ester SAGAMI CHEMICAL RESEARCH CENTER (JP) 1988-01-13 EP disclosed