SCHEMBL9854300

SCHEMBL9854300

FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)CC(Br)Cc1ccccc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 1/20 0.34
CPA1 P15085 1/20 0.34
TRPA1 O75762 1/20 0.33
ALDH1A1 P00352 1/20 0.33
TSHR P16473 1/20 0.33
CA1 P00915 2/20 0.33
CA2 P00918 2/20 0.33
MMP1 P03956 2/20 0.33
MMP2 P08253 2/20 0.33
MMP9 P14780 2/20 0.33
MMP8 P22894 2/20 0.33
MMP13 P45452 2/20 0.33
CTRB1 P17538 1/20 0.33
TAAR1 Q96RJ0 4/20 0.32
SLC6A2 P23975 2/20 0.32
SIGMAR1 Q99720 2/20 0.32
MAOA P21397 1/20 0.32
SLC6A4 P31645 1/20 0.32
SLC6A3 Q01959 1/20 0.32
CYP2A6 P11509 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10731618 0.80 EPHX1 (0.34) EPHX1CPA1TAAR1SLC6A2SIGMAR1
SCHEMBL31433296 0.79 MTNR1A (0.39) EPHX1CPA1ALDH1A1SLC6A2SIGMAR1
SCHEMBL9854342 0.78 EPHX1 (0.35) EPHX1CPA1TAAR1SLC6A2SIGMAR1
SCHEMBL10489340 0.76 CYP1A2 (0.56) CPA1CYP1A2
SCHEMBL29173885 0.73 CPA1 (0.35) EPHX1CPA1TAAR1SLC6A2SIGMAR1
SCHEMBL18918251 0.73 HTR2A (0.37) TSHRTAAR1SLC6A3CYP2D6
SCHEMBL7252952 0.71 EPHX1 (0.55) EPHX1TRPA1ALDH1A1TSHRTAAR1
SCHEMBL9854396 0.70 EPHX2 (0.46) CPA1ALDH1A1MMP8CYP1A2
SCHEMBL9849222 0.69 CES1 (0.41) TRPA1ALDH1A1TSHRTAAR1MAOA
SCHEMBL9220176 0.69 TSHR (0.35) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0252736-B1 PROCESS FOR PREPARING FLUORINE-CONTAINING CARBOXYLIC ACID ESTER SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-07-24 EP disclosed
EP-0252736-A2 Process for preparing fluorine-containing carboxylic acid ester SAGAMI CHEMICAL RESEARCH CENTER (JP) 1988-01-13 EP disclosed