Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1033377 | 0.80 | PTGS2 (0.47) | HDAC4HDAC6HDAC3HDAC1CES1 | |
| SCHEMBL28842374 | 0.77 | CYP2D6 (0.46) | CES1KMT2ACYP2D6SRCALOX5 | |
| SCHEMBL585192 | 0.77 | CYP2D6 (0.52) | KEAP1NFE2L2CYP2D6SRCALOX5 | |
| SCHEMBL7787872 | 0.77 | CYP2D6 (0.52) | KEAP1NFE2L2CYP2D6SRCALOX5 | |
| SCHEMBL22351001 | 0.75 | SRC (0.56) | HDAC4HDAC6HDAC3HDAC1CES1 | |
| SCHEMBL15342224 | 0.75 | CYP3A4 (0.49) | DPP4CES1KMT2ACYP2D6SRC | |
| SCHEMBL4568744 | 0.75 | CYP3A4 (0.49) | DPP4CES1KMT2ACYP2D6SRC | |
| SCHEMBL6724975 | 0.75 | CYP2D6 (0.44) | CES1KMT2ACYP2D6SRCALOX5 | |
| SCHEMBL5692026 | 0.74 | HDAC4 (0.49) | DPP4DPP7HDAC4HDAC6HDAC3 | |
| SCHEMBL7475015 | 0.74 | ALOX5 (0.55) | CYP2D6SRCALOX5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0253500-B1 | ACYLANILIDE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-02-27 | — | — | EP | disclosed |
| US-4880839-A | PROGESTATIONAL ACTIVITY | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-11-14 | — | — | US | disclosed |
| EP-0253500-A2 | Acylanilide derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-01-20 | — | — | EP | disclosed |