Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9854699 | 0.85 | MTNR1A (0.52) | MTNR1AMTNR1BPDE4APDE4BPDE4C | |
| SCHEMBL9854743 | 0.83 | MTNR1A (0.54) | MTNR1AMTNR1BKMT2AMEN1ALDH1A1 | |
| SCHEMBL11138133 | 0.81 | MTNR1A (0.53) | MTNR1AMTNR1BTAS1R3TAS1R1SMN1; SMN2 | |
| SCHEMBL7273542 | 0.81 | MTNR1A (0.53) | MTNR1AMTNR1BTAS1R3TAS1R1SMN1; SMN2 | |
| SCHEMBL7270673 | 0.81 | MTNR1A (0.53) | MTNR1AMTNR1BTAS1R3TAS1R1SMN1; SMN2 | |
| SCHEMBL23772365 | 0.81 | MTNR1A (0.53) | MTNR1AMTNR1BPDE4APDE4BPDE4C | |
| SCHEMBL2464892 | 0.79 | MTNR1A (0.51) | MTNR1AMTNR1BPDE4APDE4BPDE4C | |
| SCHEMBL9854682 | 0.77 | MTNR1A (0.53) | MTNR1AMTNR1BKMT2AMEN1TAS1R3 | |
| SCHEMBL1988494 | 0.75 | PDPK1 (0.61) | MTNR1AMTNR1BPDE4APDE4BPDE4C | |
| SCHEMBL8029932 | 0.75 | PDPK1 (0.61) | MTNR1AMTNR1BPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420064-A2 | Substituted 2-amidotetralins as melatonin agonists and antagonists | NORTHWESTERN UNIVERSITY (US) | 1991-04-03 | — | — | EP | disclosed |