Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15079909 | 0.79 | MAPT (0.52) | TSHRLMNAMAOAMEN1CYP1A2 | |
| SCHEMBL2529599 | 0.79 | LMNA (0.52) | TSHRLMNAMAOAPTGS1MTNR1A | |
| Benzene SCHEMBL1836843 | 0.77 | TSHR (0.95) | TSHRLMNAGABRA1GABRB2PTGS1 | |
| SCHEMBL6535408 | 0.76 | LMNA (0.44) | TSHRLMNAGABRA1GABRB2MAOA | |
| SCHEMBL21810947 | 0.75 | LMNA (0.61) | LMNAMAOAPTGS1MTNR1AMTNR1B | |
| SCHEMBL15079881 | 0.75 | LTA4H (0.49) | LMNACYP2D6ADRB2ADRB1ADRB3 | |
| SCHEMBL20721726 | 0.74 | TSHR (1.00) | TSHRLMNAGABRA1GABRB2PTGS1 | |
| SCHEMBL282162 | 0.74 | TSHR (1.00) | TSHRLMNAGABRA1GABRB2PTGS1 | |
| SCHEMBL15485172 | 0.74 | TSHR (1.00) | TSHRLMNAGABRA1GABRB2PTGS1 | |
| SCHEMBL5819894 | 0.74 | TSHR (0.61) | TSHRLMNAGABRA1GABRB2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0428423-A2 | Aryloxy alkyl benzenes, processes for their preparation and pharmaceutical compositions containing them | LIPHA S.A. (FR) | 1991-05-22 | — | — | EP | disclosed |