Fumaric Acid

Fumaric Acid

SCHEMBL985493

N.O=C(O)/C=C/C(=O)O.[Fe]

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol

The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A known ✓ Q03164 2/20 0.39
MEN1 known ✓ O00255 1/20 0.39
TSHR P16473 4/20 0.82
TP53 P04637 1/20 0.82
EGLN1 Q9GZT9 1/20 0.82
EGLN3 Q9H6Z9 1/20 0.82
HCAR2 Q8TDS4 4/20 0.47
GABRR1 P24046 2/20 0.42
GABRR2 P28476 2/20 0.42
BLM P54132 2/20 0.42
TDP1 Q9NUW8 2/20 0.42
LMNA P02545 2/20 0.42
GABRR3 A8MPY1 1/20 0.42
APEX1 P27695 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
ALDH1A1 P00352 3/20 0.41
GAA P10253 1/20 0.41
ALOX15 P16050 1/20 0.41
RECQL P46063 1/20 0.41
HSD17B10 Q99714 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Maleic Acid SCHEMBL988578 1.00 TSHR (0.82) TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL985495 1.00 TSHR (0.82) TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL6466117 0.95 TSHR (0.90) TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL342742 0.95
Maleic Acid SCHEMBL716254 0.95
Fumaric Acid SCHEMBL41492 0.95
Fumaric Acid SCHEMBL41491 0.95 TSHR (0.90) TSHRTP53EGLN1EGLN3HCAR2
Maleic Acid SCHEMBL532168 0.95
Fumaric Acid SCHEMBL6466120 0.95 TSHR (0.90) TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL2138822 0.95 TSHR (0.90) TSHRTP53EGLN1EGLN3HCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114766661-A Formula and preparation method of special nutrition diet for speed and strength sports 武汉万松堂生物医药科技有限公司 2022-07-22 CN claimed
EP-3083978-A1 MEDIA FOR CELL CULTURE Essential Pharmaceuticals, LLC (US) 2016-10-26 EP claimed
CN-106062205-A Cell culture medium 基本药品有限责任公司 2016-10-26 CN claimed
US-20150329830-A1 MYELOMA CELL CULTURE IN TRANSFERRIN-FREE LOW IRON MEDIUM CAMBRIDGE ANTIBODY TECHNOLOGY LIMITED (GB) 2015-11-19 US claimed
WO-2015095651-A1 MEDIA FOR CELL CULTURE ESSENTIAL PHARMACEUTICALS, LLC (US) 2015-06-25 WO claimed
EP-2776558-A1 KIT COMPRISING SERUM REPLACEMENT AND LABILE FACTORS Essential Pharmaceuticals, LLC (US) 2014-09-17 EP claimed
CN-103958665-A Kit comprising a serum replacement and a labile factor ESSENTIAL PHARMACEUTICALS LLC 2014-07-30 CN claimed
US-20130183714-A1 MYELOMA CELL CULTURE IN TRANSFERRIN-FREE LOW IRON MEDIUM MEDIMMUNE LIMITED (GB) 2013-07-18 US claimed
US-20130130373-A1 Kit Comprising Serum Replacement and Labile Factors ESSENTIAL PHARMACEUTICALS, LLC (US) 2013-05-23 US claimed
WO-2013071151-A1 KIT COMPRISING SERUM REPLACEMENT AND LABILE FACTORS ESSENTIAL PHARMACEUTICALS, LLC (US) 2013-05-16 WO claimed
US-8361797-B2 Myeloma cell culture in transferrin-free low iron medium MEDIMMUNE LIMITED (GB) 2013-01-29 US claimed
EP-1651754-B1 MYELOMA CELL CULTURE IN TRANSFERRIN-FREE LOW IRON MEDIUM CAMBRIDGE ANTIBODY TECH (GB) 2007-04-11 EP claimed
US-20070031964-A1 Myeloma cell culture in transferrin-free low iron medium MEDIMMUNE LIMITED (GB) 2007-02-08 US claimed
JP-2007501606-A 2007-02-01 JP claimed
EP-1651754-A1 MYELOMA CELL CULTURE IN TRANSFERRIN-FREE LOW IRON MEDIUM Cambridge Antibody Technology Limited (GB) 2006-05-03 EP claimed
WO-2005014800-A1 MYELOMA CELL CULTURE IN TRANSFERRIN-FREE LOW IRON MEDIUM CAMBRIDGE ANTIBODY TECHNOLOGY LIMITED (GB) 2005-02-17 WO claimed
CN-1136400-A Fruit fragrant composite mineralizing nutrient tea WUEN GARMENT AND DRESS PERSONA (CN) 1996-11-27 CN claimed
CN-115943157-A Use of plant protein homologues in culture media 耶路撒冷希伯来大学伊森姆研究发展公司 2023-04-07 CN disclosed
WO-2005014800-A1 MYELOMA CELL CULTURE IN TRANSFERRIN-FREE LOW IRON MEDIUM CAMBRIDGE ANTIBODY TECHNOLOGY LIMITED (GB) 2005-02-17 WO disclosed
CN-1136400-A Fruit fragrant composite mineralizing nutrient tea WUEN GARMENT AND DRESS PERSONA (CN) 1996-11-27 CN disclosed