SCHEMBL9854943

SCHEMBL9854943

COC(=O)CC1CCc2cc(SC(=O)N(C)C)ccc2C1=O

nearest known ligand 0.43

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CYP24A1 Q07973 6/20 0.43
CYP26A1 O43174 5/20 0.43
ACHE P22303 1/20 0.41
CYP27A1 Q02318 3/20 0.40
CYP19A1 P11511 2/20 0.40
DGAT1 O75907 1/20 0.40
ITGB3 P05106 3/20 0.39
ITGA2B P08514 3/20 0.39
THRA P10827 1/20 0.39
THRB P10828 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9854995 0.89 METAP1 (0.44) ACHECYP19A1THRATHRB
SCHEMBL9855381 0.79 CYP26A1 (0.60) CYP24A1CYP26A1CYP27A1CYP19A1DGAT1
SCHEMBL9855296 0.78 CYP24A1 (0.63) CYP24A1CYP26A1ACHECYP27A1CYP19A1
SCHEMBL14454770 0.75 ITGB3 (0.53) CYP24A1CYP26A1DGAT1ITGB3ITGA2B
SCHEMBL31374633 0.75 ALDH1A1 (0.52) CYP24A1ACHECYP27A1CYP19A1DGAT1
SCHEMBL6644734 0.75 ALDH1A1 (0.52) CYP24A1ACHECYP27A1CYP19A1DGAT1
SCHEMBL12799028 0.75 PPARD (0.43) ACHE
SCHEMBL3023059 0.72 FFAR1 (0.51) ACHE
SCHEMBL4622270 0.71 CYP24A1 (0.61) CYP24A1CYP26A1ACHECYP27A1CYP19A1
SCHEMBL7302984 0.71 CYP19A1 (0.60) CYP24A1CYP26A1ACHECYP27A1CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4983628-A ANTIASTHMATIC, ANTIALLERGIC, ANTIINFLAMMATORY AND CYTOPROTECTIVE AGENTS MERCK FROSST CANADA, INC. (CA) 1991-01-08 US disclosed
EP-0140684-B1 LEUKOTRIENE ANTAGONISTS MERCK FROSST CANADA INC. (CA) 1990-07-11 EP disclosed
US-4683325-A ANTIINFLAMMATORY AGENTS, ANTIALLERGENS MERCK FROSST CANADA, INC. (CA) 1987-07-28 US disclosed
EP-0140684-A2 Leukotriene antagonists MERCK FROSST CANADA INC. (CA) 1985-05-08 EP disclosed